C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
trans-C75 Chemical Structure CAS No. : 191282-48-1 SizePriceStockQuantity Free Sample (0.1-0.5 mg) Apply now 10 mM * 1 mL in DMSO ￥1211 ...trans-C75 | (±)-C75 | Fatty Acid Synthase (FASN) | Inhibitor | inhibitor | inhibittrans-C75 ((±)-C75) 是 C75 的对映异构体，C75 是脂肪酸合成酶 (FASN) 的抑制剂。- 高纯度，全球文献引用。trans